Grapefruit-seed extract attenuates ethanol-and stress-induced gastric lesions via activation of prostaglandin, nitric oxide and sensory nerve pathways

Table 1 Effect of vehicle (saline) and GSE applied ig in graded concentrations ranging from 8 up to 64 mg/kg on the gastric acid secretion and plasma gastrin levels. Results are mean±SE from 6 determinations on 6–8 animals

Type of test	Gastric acid output	Plasma gastrin
	(μmol/30 min)	(pmol/L)
Vehicle	134 ± 11	53 ± 4
GSE (mg/kg ig)
8	131 ± 9	56 ± 6
16	118 ± 9a	69 ± 8a
32	89 ±7a	75 ± 9a
64	64 ± 5a	82 ± 10a

^aP<  0.05 vs vehicle.