Effects of glucocorticoids on the growth and chemosensitivity of carcinoma cells are heterogeneous and require high concentration of functional glucocorticoid receptors

Figure 1 Effect of DEX on the growth and chemosensitivity in carcinoma cell lines. Cell numbers were measured by MTT assay and were plotted as a percentage of the control (cells not exposed to drugs); A: Growth of MCF-7, MCF-7/MXR1, MCF-7/TPT300, and HeLa cells were suppressed by DEX. Data of AGS represent the other 10 cell lines, growth of which was not affected by DEX; B: SiHa cells pretreated with DEX for 3 h were more sensitive to cisplatin; C and D: Pretreatment with DEX 1 mmol/L for 24 h diminished cisplatin cytotoxicity in H460 cells and Hep3B cells; E: Data of AGS represent the seven cell lines (AGS, N87, Caski, Hut 7, SNU1, NPC-TW01, and NPC-TW04), of which cytotoxicity of cisplatin was not affected by DEX. All values represent mean±SD of six separate wells.