Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma

Figure 2 Tumorigenicity and metastasis in vivo enhanced by MT1-MMP. A1-4: Large primary tumor nodule with prominent metastases produced by MT1-MMP overexpression; B1-4: Small primary tumor nodule and rare metastasis produced by vector control transfectants; C1-2: Tumor-free control liver injected with saline. Primary tumors, metastases, and injection site were indicated by dotted lines, arrows, and an asterisk, respectively. Sections from all tissues collected were then subjected to AFP staining.