Apoptosis induced by nucleosides in the human hepatoma HepG2

doi:10.3748/wjg.v11.i40.6381

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Oct 28, 2005 (publication date) through Jan 27, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2005; 11(40): 6381-6384
Published online Oct 28, 2005. doi: 10.3748/wjg.v11.i40.6381

Table 2 Effects of nucleosides on the cell cycle progression, caspas-3 activity and sFas-L content in HepG2 cells¹

Treatment	Control	Inosine	Cytidine	Uridine	Thymidine	Adenosine	Gaunosine
SubG1 (%)	2.6±0.8^a	3.2±0.3^a	6.9±0.2^a	6.5±1.5^a	26.8±2.3^a	9.6±1.5^a	5.7±1.2^a
G0/G1(%)	67.7±1.1^a	69.2±0.1^a	74.1±1.3^a	84.8±2.6^a	54.4±1.8^a	64.8±1.4^a	68.0±1.9^a
S (%)	15.7±0.0^a	18.8±0.3^a	8.5±0.2^a	3.1±0.3^a	12.0±0.2^a	10.6±0.4^a	17.3±0.7^a
G2/M (%)	14.0±1.9^a	8.8±0.1^a	10.5±1.0^a	5.7±0.8^a	6.8±0.8^a	15.0±0.9^a	9.0±1.3^a
Caspase-3 (%)²	100±0^a	101±5^a	97±6^a	98±5^a	148±2^a	104±4^a	100±3^a
sFas-L (pg/mL)	0.11±0.01^a	0.14±0.01^a	0.08±0.03^a	0.15±0.03^a	0.17±0.02^a	0.15±0.07^a	0.10±0.03^a

¹Cells were treated with or without nucleosides for 12 h. The contents of inosine, cytidine, uridine, and thymidine in the mediums were 30 mmol/L, respectively, and, the contents of adenosine and guanosine were 0.5 mmol/L. Values are expressed as the mean±SD of four independent experiments.

^aP<0.05 vs others.

²Caspase-3 activity was shown as percentage to compare with control group.

Citation: Yang SC, Chiu CL, Huang CC, Chen JR. Apoptosis induced by nucleosides in the human hepatoma HepG2. World J Gastroenterol 2005; 11(40): 6381-6384
URL: https://www.wjgnet.com/1007-9327/full/v11/i40/6381.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i40.6381