Classifying genotype F of hepatitis B virus into F1 and F2 subtypes

Table 3 Sequence homology of seven HBV/F2 isolates among themselves and to seven HBV isolates representative of HBV/F1 as well as the other genotypes (A, B, C, D, E, and G)

Genomic regions	Homology within seven HBV/F2 isolates and that of HBV/F2 to seven representative of HBV/F1 as well as genotypes A, B, C, D, E, and G1
	F2	F1	A	B	C	D	E	G
Full genome	97.5	91.6	86	85.9	85.7	85.7	86.1	84.5
	(96.3–99.2)	(91.0–92.1)	(85.4–86.5)	(85.5–86.2)	(85.2–86.0)	(85.1–86.3)	(85.6–86.4)	(84.1–84.8)
PreS1 region	98.1	90	77.3	75.7	78.9	79.3	81.4	80.6
	(97.2–99.4)	(89.1–90.5)	(76.8–78.2)	(75.1–76.5)	(77.9–80.1)	(78.3–80.2)	(80.7–82.0)	(80.4–81.1)
PreS2 region	97.4	90.9	82.9	79.2	82.6	81.2	83.3	81.3
	(92.7–100)	(86.1–92.7)	(78.0–84.2)	(75.8–80.6)	(79.4–83.6)	(77.6–82.4)	(79.4–84.2)	(77.0–83.0)
S gene	99.4	96.4	92.2	92.6	91.3	92.7	92.6	92.8
	(98.7–99.9)	(95.9–96.8)	(91.8–92.5)	(92.5–92.8)	(91.0–91.6)	(92.4–93.0)	(92.2–92.8)	(92.4–93.0)
C gene	95.8	91.9	84.8	87.3	86.6	84.9	85.8	87.2
	(90.9–100)	(88.8–93.5)	(83.0–85.8)	(85.1–88.6)	(84.8–87.5)	(82.8–86.6)	(84.1–86.8)	(84.9–88.2)
P gene	97.9	91.7	86.2	85.8	86.3	86.1	86.5	86.1
	(96.6–99.1)	(90.9–92.0)	(85.7–86.6)	(85.4–86.0)	(86.1–86.6)	(85.5–86.4)	(86.2–86.8)	(85.7–86.4)
X gene	97.1	91.1	87.7	88.7	85.4	89.2	88.3	84.2
	(94.2–99.8)	(89.3–92.3)	(86.5–88.7)	(86.8–90.1)	(84.7–86.8)	(88.0–90.2)	(87.1–89.5)	(85.0–83.7)

¹The seven representatives of each genotype were: F1 (AB064316 [USF2573 isolate]), A (AB064314), B (D23678), C (S75184), D (D23681), E (X75657) and G (AF160501).