Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver

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Oct 28, 2005 (publication date) through Apr 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Oct 28, 2005; 11(40): 6262-6268
Published online Oct 28, 2005. doi: 10.3748/wjg.v11.i40.6262

Table 1 Scheme for the systematic assessment of histological features in liver cell nodules in cirrhotic livers

Feature	Modality of assessment
Nodule maximum diameter			Measurement in millimeter
Solitary arterioles			Average of individual arteries ×100 (medium power field, MPF) fields
Mitotic activity			Number of mitoses per 10 ×400 (10 high power fields, 10 HPF) fields
Trabecular thickness			Number of liver cells forming trabecular (LCT) width
Vascular invasion					Present/absent
Capsular invasion					Present/absent
Necrosis²				Present/absent
Nodule heterogeneity¹				Present/absent
Reticulin loss³	None	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Capillarization (CD34)³	None	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Cellular atypia³	None	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5

¹Phenotypically recognizable “clonal” changes e.g. clear cell change, fatty change, microacinar structures;

²excluding post-treatment necrosis;

³see text pages 5-6.

Citation: Quaglia A, Jutand M, Dhillon A, Godfrey A, Togni R, Bioulac-Sage P, Balabaud C, Winnock M, Dhillon A. Classification tool for the systematic histological assessment of hepatocellular carcinoma, macroregenerative nodules, and dysplastic nodules in cirrhotic liver. World J Gastroenterol 2005; 11(40): 6262-6268
URL: https://www.wjgnet.com/1007-9327/full/v11/i40/6262.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i40.6262