Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease

Figure 1 Serum levels of type IV collagen, PIIIP, HA and YKL-40 with respect to stage of liver fibrosis (F0-4). The box represents the interquartile range. The whiskers indicate the highest and lowest values, and the line across the box indicates the median value. Overall significance of differences among 5 groups was determined by ANOVA: for type IV collagen, F = 9.076, P<0.0001; for PIIIP, F = 9.636, P<0.0001; for HA, F = 13.128, P<0.0001; and for YKL-40, F = 8.016, P<0.0001.