Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats

Table 2 Activity values of cathepsins B and L and their inhibitors in hepatoma Morris 5123 (median, mean±SD, range).

	Before treatment			After treatment
	Cathepsin B	Cathepsin L	Endogenous (CPI)	Cathepsin B	Cathepsin L	Endogenous (CPI)
	8.2	3.2	12.2
Control negative(Healthy)	9.4±1.5	3.6±1.3	12.8±2.6		No changes
	(1.5-12.7)	(1.3-7.4)	(3.4-15.7)
	67.6	28.4	8.5	7.6	3.4	78.5
Control positive (Tumor)	68.9±23.6	28.8±10.4	9.0±2.3	8.4±2.5	3.8±1.6	79.4±22.5
	(19.4-89.2)	(6.4-35.2)	(3.2-12.5)	(3.4-10.2)	(2.2-5.7)	(23.9-96.5)
	46.6	17.2	4.3	6.3	2.2	63.2
Liver	47.9±20.5	18.8±8.6	5.6±1.1	7.8±2.9	2.7±1.0	64.8±25.7
	(21.3-68.2)	(6.4-25.8)	(1.8-7.7)	(2.9-8.6)	(1.2-5.4)	(27.9-74.3)
	26.7	10.8	3.6	2.6	1.5	45.8
Lung	27.9±18.3	12.0±4.2	4.6±0.9	2.9±0.5	2.0±0.4	47.1±21.5
	(15.8-38.9)	(6.4-19.4)	(1.0-6.8)	(0.8-3.7)	(0.4-3.1)	(23.7-56.0)
	12.6	8	1.2	1.5	1.6	114.8
Sera	13.9±4.2	9.3±2.8	1.6±0.1	3.7±0.9	1.7±0.6	115.3±45.4
	(5.6-18.5)	(2.9-11.3)	(0.2-2.3)	(0.04-3.2)	(0.07-3.8)	(44.7-123.9)
P		≤0.0001		NS	NS	≤0.0001

The significance of differences in median values of tumor and control were calculated after and before treatment by Wilcoxon rank test. NS, Not significant.