Effect of 2-amino-2-[2-(4-octylphenyl) ethyl] propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice

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Jan 28, 2005 (publication date) through Nov 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 28, 2005; 11(4): 573-576
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.573

Table 1 Effect of FTY 720 on serum ALT and AST activities in BCG+LPS -induced liver injury (mean±SD).

Group	Number of mice	sALT Karman’s units/dL	sAST Karman’s units/dL
Normal	10	19.65±11.87^a	108.00±22.37^a
BCG (3 mg/mouse) +LPS (7.5 mg/mouse)	10	234.24±143.17	254.71±101.45
BCG (3 mg/mouse) +LPS (7.5 mg/mouse)	10	168.05±87.19	220.31±54.96
+FTY 720 1 mg/kg BCG (3 mg/mouse)+LPS (7.5mg/mouse)+FTY 720 3 mg/kg	10	162.411±77.43	214.21±32.34
BCG (3 mg/mouse)+LPS (7.5 mg/mouse)+FTY 720 6 mg/kg	10	119.411±77.45^a	183.00±46.29^a

^aP<0.05 vs BCG (3 mg/mouse)+LPS (7.5 μg/mouse) model groups.

Citation: He JH, Zhang HN, Lin ZB. Effect of 2-amino-2-[2-(4-octylphenyl) ethyl] propane-1,3-diol hydrochloride (FTY 720) on immune liver injury in mice. World J Gastroenterol 2005; 11(4): 573-576
URL: https://www.wjgnet.com/1007-9327/full/v11/i4/573.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i4.573