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©2005 Baishideng Publishing Group Inc.
World J Gastroenterol. Jan 28, 2005; 11(4): 538-544
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.538
Published online Jan 28, 2005. doi: 10.3748/wjg.v11.i4.538
Table 7 Histological scoring (effect of PACAP receptor antagonists) (mean±SE).
Group | Hemorrhage | Parenchymal necrosis | Vacuolization | Inflammatory infiltration |
Caerulein-induced pancreatitis | 1.67±0.60 | 2.5±0.22 | ||
Sodium taurocholate-induced pancreatitis | 1.5±0.67 | 2.5±0.49 | 0.5±0.49 | 3 |
10 μg PACAP6-27 | 1.5±0.5 | |||
100 μg PACAP6-27 | 0.83±0.54 | |||
Caerulein+10 μg PACAP6-27 | 0.83±0.54 | 0.17±0.17 | 1.83±0.60 | 2.5±0.5 |
Caerulein+100 μg PACAP6-27 | 1.67±0.49 | 1±0.52 | 2.17±0.31 | 2.5±0.22 |
Sodium taurocholate+10 μg PACAP6-27 | 1.5±0.67 | 3 | 1.33±0.61 | 3 |
Sodium taurocholate+100 μg PACAP6-27 | 1.5±0.5 | 2.83±0.17 | 2±0.52 | 3 |
10 μg (4-Cl-D-Phe6, Leu17) VIP | 0.33±0.33 | 2±0.63 | ||
100 μg (4-Cl-D-Phe6, Leu17) VIP | 1±0.63 | 1.67±0.60 | ||
Caerulein+10 μg (4-Cl-D-Phe6, Leu17) VIP | 0.17±0.17 | 0.17±0.17 | 0.67±0.40 | 2±0.51 |
Caerulein+100 μg (4-Cl-D-Phe6, Leu17) VIP | 0.33±0.33 | 1.67±0.49 | 2.17±0.48 | |
Sodium taurocholate+10 μg (4-Cl-D-Phe6, Leu17) VIP | 1.5±0.56 | 2.5±0.49 | 1.17±0.60 | 3 |
Sodium taurocholate+100 μg (4-Cl-D-Phe6, Leu17) VIP | 1.5±0.67 | 2.33±0.33 | 1.83±0.60 | 3 |
- Citation: Chen YD, Zhou ZG, Wang Z, Gao HK, Yan WW, Wang C, Zhao GP, Peng XH. Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats. World J Gastroenterol 2005; 11(4): 538-544
- URL: https://www.wjgnet.com/1007-9327/full/v11/i4/538.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i4.538