Pituitary adenylate cyclase activating-peptide and its receptor antagonists in development of acute pancreatitis in rats

Table 1 Ascites/peritoneal fluid and their gross appearance (action of PACAP) (mean±SE).

Group	Volume ofascites (mL)	Ascites amylase(IU/L)	Nucleated cells in ascites (×108/L)	Saponifi -cation (n)	Hemorr -hage (n)
Control		213±44/7	1.71±1.02/9
Caerulein-induced pancreatitis		39075±50341/3	7.54±2.85/4a
Sodium taurocholate-induced pancreatitis	3.55±1.86/12	11 463±5 486/10a	2.9±3.06/8	2	3
PACAP 5 μg/kg
PACAP 10 μg/kg
PACAP 15 μg/kg
PACAP 30 μg/kg			3.26±1.89/6
Sodium taurocholate+PACAP 5 μg	2.33±0.82/6	26917±11145/6a	2.3±0.98/6	2/6	4/6
Sodium taurocholate+PACAP 10 μg	4.77±2.44	5956±3546/8a	1.76±1.02/11	7	11
Caerulein+PACAP 15 μg	0.55±0.96	926/1		1	1
Caerulein+PACAP 30 μg	0.91±0.83	63918±82884/8	1.73±1.23/8	1	3

^aP<0.05 vs normal control.