NF-kB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

Figure 4 Characterization of the upregulated genes co-cultured with H pylori for 3 h (n = 566). A: The bar represents the number of 566 upregulated genes among 3 228 analyzed genes (566 genes). B: The genes induced by cagPAI-positive H pylori infection among the 566-H pylori-induced genes (476 genes). C: The contribution of NF-kB or ERK signaling pathway among thecagPAI-dependent gene expression. Among the 476-cagPAI-dependent genes, 66% (315 genes) were also involved in the NF-kB- and/or ERK-signaling activation, whereas 34% (161 genes) of 476 genes were dependent on cagPAI but not involved in either NF-kB or ERK signaling activation.