NF-kB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

Figure 3 Schematic representation of the distribution of genes affected by wild-type H pylori infection. The complete upregulated genes at 3 h after infection is represented by the circle as a whole. The expression of 367 genes (65%) of the 566 genes upregulated by wild type H pylori was suppressed by pre-incubation with APDC, an inhibitor of NF-kB. On the other hand, pre-incubation with PD98059, an inhibitor of ERK, suppressed the expression of 429 genes (76%) of the 566 genes upregulated by wild type H pylori. Expression of 475 of the 566 genes (84%) was induced under NF-kB and/or ERK signaling activation, whereas changes in the remaining 16% are NF-kB or ERK signaling independent.