NF-kB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

Table 3 Genes undergoing most striking upregulation during H pylori-infection in vitro. Values show the mean change in gene expression from two separate microarray experiments in vitro(shown at “1.5, 3, 6, and 12 h”. Significantly upregulated values are shown in bold (above threefold)

Acc. Number	Gene Symbol	Name	Function	1.5h	3h	6h	12h
U79243	LZTR1	leucine-zipper-like transcriptional regulator 1	transcription	5.08	3.08	0.95	2.30
X61118	LMO2	LIM domain only 2 (rhombotin-like 1)	tumor associated	2.53	16.24	0.28	1.04
BC004247	RAC1	ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)	adhesion/cytoskeleton	1.13	4.78	0.89	1.29
AF005043	PARG	poly (ADP-ribose) glycohydrolase	metabolism	0.58	0.62	14.72	0.53
U86782	POH1	26S proteasome-associated pad1 homolog	RNA/Protein processing	2.55	3.59	7.24	3.56
M62839	APOH	apolipoprotein H (beta-2-glycoprotein I)	immunity	0.49	3.49	0.65	1.47
BC004980	SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter) member 1	metabolism	4.07	0.81	0.95	1.54
Z26649	PLCB3	phospholipase C beta 3 (phosphatidylinositol-specific)	tumor associated	2.49	3.32	0.75	2.52
M62399	RELA	v-rel reticuloendotheliosis viral oncogene homolog A nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 p65 (avian)	apoptpsis	2.84	3.24	1.43	1.13
BC000665	TCP1	t-complex 1	RNA/Protein processing	1.73	3.21	1.05	1.41
V01512	c-fos	V01512|HSCFOS Human cellular oncogene c-fos (complete sequence).	tumor associated	37.81	2.48	0.57	0.91
BC000117	GMDS	GDP-mannose 46-dehydratase	metabolism	2.63	4.37	2.28	3.75
L29218	CLK2	CDC-like kinase 2	growth/maintenance	1.46	4.03	1.96	0.60
BC000771	NTRK1	neurotrophic tyrosine kinase receptor type 1	tumor associated	3.33	3.47	1.42	3.59
X68836	MAT2A	methionine adenosyltransferase II alpha	metabolism	3.14	2.95	0.85	1.28
X94232	MAPRE2	microtubule-associated protein RP/EB family member 2	growth/maintenance	0.58	3.23	0.69	0.29
X80200	TRAF4	TNF receptor-associated factor 4	signal transduction	3.20	3.02	3.67	1.08
D76444	ZFP103	zinc finger protein 103 homolog (mouse)	growth/maintenance	1.38	2.63	3.99	1.78