NF-kB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection

Table 2 The functional profiles of the H pylori-induced changes in gene expression in vitro. Cluster represents the assigned cluster numbers in Figure 1C. Functions were defined by using the Onto-Express program, using hypergeometric distribution to determine the significance of differences (n≥5, P<0.05, see Materials and methods)

Cluster	Function	No. of the genes (Total)	P-value
C-1	Chaperon activity	12 (31)	0.019
	Transcription regulator activity	29 (92)	0.033
C-2	Apoptosis regulator activity	7 (9)	<0.01
	Cell adhesion molecule activity	18 (39)	<0.01
	Signal transducer activity	47 (132)	0.034
	Transcription regulator activity	9 (20)	0.037
	Structural molecular activity	40 (113)	0.049
C-3	Antioxidant activity	6 (8)	<0.01
C-4	Lyase activity	8 (10)	0.011
	Chaperon activity	10 (31)	0.037