Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease

Table 2 PTGS2 haplotype frequencies and odds ratios for IBD

Haplotype1	Controls	UC cases		CD cases		UC+CD cases2
	n (%)	n (%)	OR(95% CI)	n (%)	OR (95% CI)	n (%)	OR (95% CI)3
AGTT	471 (64.7)	193 (65.6)	1.00 (Ref.)	183 (62.7)	1.00 (Ref.)	376 (64.2)	1.00 (Ref.)
AGTC	147 (20.2)	55 (18.7)	0.91 (0.64 - 1.30)	54 (18.5)	0.95 (0.66 - 1.35)	109 (18.6)	0.93 (0.69 - 1.24)
GCGC	64 (8.8)	22 (7.5)	0.84 (0.50 - 1.39)	27 (9.2)	1.09 (0.67 - 1.75)	49 (8.4)	0.96 (0.63 - 1.45)
ACGC	25 (3.4)	8 (2.7)	0.78 (0.35 - 1.73)	7 (2.4)	0.72 (0.31 - 1.66)	15 (2.6)	0.75 (0.36 - 1.51)
AGGT	2 (0.3)	10 (3.4)	12.2 (2.97 – inf.)	9 (3.1)	11.58 (2.79 -inf.)	19 (3.2)	11.9 (2.83 – 105.76)
Rare4	19 (2.6)	6 (2.0)	0.77 (0.31 - 1.90)	12 (4.1)	1.63 (0.78 - 3.37)	18 (3.1)	1.19 (0.61 – 2.29)

¹The order of SNPs in the haplotypes is PTGS2.401, PTGS2.926, PTGS2.5209, PTGS2.8473 .

²UC and CD combined.

³ORs are not corrected, they are based on population level haplotype frequencies and are relative to the most common haplotype (AGTT).

⁴Rare haplotypes (frequency ≤1% in both cases and controls)