Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain

Figure 1 Pedigrees and DNA nucleotide sequence of the three families with disease-causing mutations of hMSH6 gene. Squares, males; circles, females; diagonal bars, deceased; unblackened symbols, no tumor; semi-blackened symbols, patients with histological-verified carcinomas; arrows, probands; mut, carries the indicated mutation. Abbreviations indicating type of tumor: CRC, colorectal; SI, small intestine; G, gastric; H, Hodgkin; End, endometrium; Pr, prostate; L, liver. Number after abbreviation indicates age at which tumor was diagnosed. Electropherograms of the wild type and mutant nucleotide sequences for V878A and Q263X mutations located in exon 4 of the hMSH6 gene.