Effect of lysozyme chloride on betel quid chewing aggravated gastric oxidative stress and hemorrhagic ulcer in diabetic rats

Table 2 Effects of lysozyme chloride on various biochemical parameters in gastric juice-irrigated stomachs of BQC-fed DM rats

	mg/kg	Acid back-diffusionμmol/stomach	Glutathioneμmol/gtissue	Lipid peroxidenmol MD/gtissue	Mucusμg/gtissue	Hemoglobinmg/stomach	Ulcer areamm2/stomach
Control
Saline		-132.0±3.4	3.6±0.3	62.6±7.0	206.4±14.6	0.4±0.2	3.2±0.5
Lysozyme chloride	500	-112.4±5.6a	4.6±0.5a	40.4±4.2a	245.4±16.5a	0.0±0.0a	0.0±0.0a
Indomethacin	5
+ lysozyme chloride	500	-140.0±7.2	2.8±0.3a	74.5±6.8a	164.6±14.2	1.0±0.5	5.6±08
BQC+DM
Saline		-365.2±20.4	0.8±0.2	160.4±11.6	83.2±10.2	8.0±0.8	396.8±34.2
Lysozyme chloride	50	-292.0±11.2a	1.7±0.3a	132.0±12.5a	126.6±7.4a	4.0±0.5a	306.0±25.2a
	100	220.2±13.0	2.4±0.3a	108.4±10.6	182.8±9.2	2.2±0.3	168.6±12.4
	500	-186.8±10.2a	3.4±0.3a	74.8±6.2	216.3±16.4	1.7±0.3a	44.5±6.4
Indomethacin	5
+ lysozyme chloride	500	-308.6±18.8a	1.5±0.2a	154.0±12.6a	140.8±11.5a	4.8±0.8a	320.4±30.4a

Data are mean±SE (n = 8).

^aP < 0.05 vs corresponding saline-group. MDA = malondialdehyde. MDA = malondialdehyde, DM = diabetes mellitus, BQC = betel quid chewing.