Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes

Table 4 ORs for analysis of correlation between exposure and genotypes

Genotypes	Cumulative VCM exposure
	≤ 15 000 mg			> 15 000 mg
	Control	Liver lesion	OR (95% CI)	Control	Liver lesion	OR (95% CI)
GSTT1
Null	15	23	1	16	14	1
GSTM1	17	9	0.3 (0.1-0.9)a	10	12	1.4 (0.5-4.1)
GSTM1
Non-null	21	21	1	16	15	1
Null	11	11	1.0 (0.4-2.8)	10	11	1.2 (0.4-3.6)
CYP2E1
c1c1	23	16	1	20	11	1
c1c2/ c2c2	9	16	2.6 (0.9-7.2)	6	15	4.6 (1.4-15.1)a
ALDH2
1-1	20	22	1	17	14	1
1-2/2-2	12	10	0.8 (0.3-2.1)	9	12	1.6 (0.5-5.0)
ADH2
1-1	2	8	1	2	1	1
1-2/2-2	30	24	0.2 (0.1-1.0)a	24	23	2.1 (0.2-24.5)

^aP < 0.05 vs≤ 15 000 mg group.