Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes

Table 3 Liver lesions status according to genotypes and variables of interest in VCM exposure group

	VCM exposure group		Adjusted OR (95%CI)
	Control(n = 58)	Liver lesions(n = 58)
GSTT1
Non-null	31 (53.4%)	37 (63.8%)	1.0 (reference)
Null 27	(46.6%)	21 (36.2%)	0.65 (0.31-1.37)
GSTM1
Non-null	37 (63.8%)	36 (62.1%)	1.0 (reference)
Null	21 (36.2%)	22 (37.9%)	1.08 (0.51-2.29)
CYP2E1
c1c1	43 (74.1%)	27 (46.6%)	1.0 (reference)
c1c2/ c2c2	13/2 (25.8%)	24/7 (53.4%)	3.29 (1.51-7.20) b
ALDH2
1-1	37 (63.8%)	36 (62.1%)	1.0 (reference)
1-2/2-2	17/4 (36.2%)	17/5 (37.9%)	1.08 (0.51-2.29)
ADH2
1-1	4 (6.9%)	9 (15.5%)	1.0 (reference)
1-2/2-2	24/30 (93.1%)	22/27 (84.5%)	0.40 (0.12-1.39)
Age (yr)
< 35	41 (70.7%)	35 (60.3%)	1.0 (reference)
≥ 35	17 (29.3%)	23 (46.6)	2.10 (0.76-3.43)
Drinking
No	53 (91.4%)	47 (81.0%)	1.0 (reference)
Yes	5 (9.6%)	11 (19.0%)	2.48 (0.80-7.66)
Smoking
No	40 (69.0%)	41 (71.7%)	1.0 (reference)
Yes	18 (31.0%)	17 (29.3%)	0.92 (0.42-2.04)

^bP < 0.01 vs control.