Low prevalence of germline hMSH6 mutations in colorectal cancer families from Spain

Table 1 Classification of colorectal cancer families, frequencies of pathogenic mutations in hMLH1 and hMSH2 genes and MSI phenotype

Clinical criteria	Number of families	hMLH1 mutations	MSH2 mutations	MSI-H	MSS	MSI untyped
Amsterdam I	56	17	15	42	13	1
Amsterdam II	11	2	2	2	7	2
Bethesda	37	5	0	6	20	11
HNPCC-like	38	0	0	3	20	5
Total	132	24	17	53	60	19