Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus

Table 4 Prognostic value of lysosomal enzyme activites in adenocarcinomas of the GEJ (mean±SE)

Prognosticcategories	Relative activity	AMAN	Specific activity	Relative activity	CB	Specific activity	Relative activity	DPP I	Specific activity
Siewert I	1.36 ± 0.19	NS	110 136 ± 20902	1.68 ± 0.37	NS	273838 ± 66573	1.37 ± 0.42	NS	1896366 ± 446446
Siewert II	1.49 ± 0.23		88413 ± 17021	2.42 ± 0.48		417978 ± 65610	2.58 ± 0.64		2673743 ± 638594
Siewert III	1.34 ± 0.19		79 101 ± 9469	2.20 ± 0.68		278994 ± 63462	2.68 ± 1.1		1861382 ± 384367
Papillary	1.54 ± 0.27	NS	92754 ± 22 466	2.79 ± 1.19	NS	368700 ± 112886	2.97 ± 1.60	NS	2156354 ± 763729
Signet-ring cell	1.42 ± 0.13		82743 ± 10 810	2.04 ± 0.27		29588 ± 58097	2.37 ± 0.59		2328450 ± 567443
Tubular	1.30 ± 0.26		90069 ± 8 722	1.80 ± 0.45		32476 ± 68549	2.10 ± 1.12		1916498 ± 504487
Grade 1	0.91 ± 0.11	P < 0.01	61931 ± 8716	0.95 ± 0.08	P < 0.01	210697 ± 54630	0.72 ± 0.06	P < 0.01	981478 ± 111507
Grade 2–3	1.63 ± 0.13		103425 ± 10283	2.75 ± 0.42		380793 ± 46390	3.14 ± 0.69		2720009 ± 332437
N0	1.00 ± 0.17	P < 0.05	67068 ± 10 377	1.03 ± 0.11	P < 0.01	201550 ± 55664	0.75 ± 0.07	P < 0.01	1053122 ± 122928
N1–N2	1.59 ± 0.13		10857 ± 10644	2.71 ± 0.43		385367 ± 44735	3.12 ± 0.69		2684187 ± 345227
Survival ≤ 2 yr	1.55 ± 0.14	NS	103466 ± 11103	2.76 ± 0.46	P < 0.01	382830 ± 49621	3.24 ± 0.74	P < 0.01	2722922 ± 373145
Survival ≥ 2 yr	1.13 ± 0.17		67052 ± 9135	1.16 ± 0.14		228650 ± 51792	0.87 ± 0.07		1194060 ± 160577
Stage II	1.19 ± 0.13	NS	80194 ± 8553	1.90 ± 0.50	NS	293720 ± 52833	1.98 ± 0.74	NS	1860244 ± 358265
Stage III	1.66 ± 0.18		102128 ± 15960	2.47 ± 0.41		36494 ± 59832	2.81 ± 0.73		2514172 ± 465458

GEJ: gastroesophageal junction; NS: non significant; N0: lymph node negative; N1–N2: lymph node positive; AMAN: α-mannosidase; CB: cathepsin B; DPP I: dipeptidyl-peptidase I.