Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus

Table 2 Specific activities of lysosomal enzymes in 18 squamous cell carcinomas of the LTE and surrounding normal mucosa (mean±SE)

Enzymes	Squamous cell carcinoma	Normal esophageal mucosa	P
AGLU	54216 ± 16793	21596 ± 4106	NS
AMAN	86987 ± 14 625	36905 ± 2287	<0.05
BGAL	225913 ± 43791	135696 ± 24644	NS
CB	535860 ± 134809	114697 ± 13037	<0.05
CL	292996 ± 56644	60964 ± 14115	<0.001
DPP I	2328558 ± 634873	401436 ± 172042	<0.05
CH	578119 ± 50491	453922 ± 54228	NS
DPP II	41816 ± 7226	34539 ± 6833	NS
GCU	134414 ± 22391	115250 ± 19634	NS
HEX	149704 ± 30362	86965 ± 15449	NS
TPP I	191061 ± 20874	112048 ± 11472	<0.001
THP	45828 ± 7921	31459 ± 7164	NS

LTE: lower third of the esophagus; NS: non significant; AGLU: α-glucosidase; AMAN: α-mannosidase; BGAL: β-galactosidase; CB: cathepsin B; CL: cathepsin L; DPP I: dipeptidyl-peptidase I; CH: cathepsin H; DPP II: dipeptidyl-peptidase II; GCU: β-glucuronidase; HEX: β-hexosaminidase B; TPP I: tripeptidyl-peptidase I; THP: thimet oligopeptidase (pmol /h·mg).