Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis

Table 3 Comparison of clinical data for cholelithiasis patients and healthy controls

	Cholelithiasis patients (n = 372)		Control group (n = 293)		P (χ2 test )(for age by student’s t test)
	n	%	n	%
Gender (M/F)	157/215		135/158		NS
Age (yr, mean±SD)	53.0±14.9		51.5±10.6		NS
UGT1A1 genotype
Wild type	180	48.4	143	48.8	NS
Heterozygous variation in promoter area (6/7)	60	16.1	60	20.5	NS
Heterozygous variation within
coding region	96	25.8	64	21.8	NS
211 G→A/normal	89		57
1 091 C→T/normal	6		7
1 456 T→G/normal	1
Compound heterozygous variation	20	5.4	23	7.9	NS
6/7, 211 G→A/normal	10		4
6/7, 686 C→A/normal	8		14
6/7, 1 091 C→T/normal			1
6/7, 211 G→A/normal, 686 C→A/ normal			1
6/7, 686 C→A/normal, 1 091 C→T/normal	1		1
211 G→A/normal, 1 091 C→T/ normal	1		1
Homozygous variation	16	4.3	3	1	0.012
7/7	5
211 G→A /G→A	4		3
7/7, 686 C→A /normal	7		0
G6PD deficiency	10	2.7	7	2.4	NS
Thalassemia	19	5.1	15	5.1	NS

6/7: A(TA)₆TAA/A(TA)₇TAA, 7/7: A(TA)₇TAA/A(TA)₇TAA in the promoter area of UGT1A1 gene.