Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock

Figure 1 Sections of ileum following ischemia-reperfusion injury after resuscitation of hemorrhagic shock. A: Shedding of cell at the tip of the villi is apparent (1 h); B: Notes the sloughed epithelial cells detached from the villi and some regions of the villi are destroyed, goblet cells reside throughout the length of the villi (3 h); C, D: extensive denudation and collapse of the villi and the enterocytes in the upper of the villi had lifted and detached from the villi (3 h); E: the tip of the villi was denuded, but some of the goblet cells still remained on the surface (3 h); F: Restitution is nearly completed and the area of the villi covered by goblet cells and their number are decreased (6 h); G: The restitution of the villi is complete except for the shortening of the villous height and goblet cells cover the villi (12 h). Epithelial cells are lifted off the basement membrane after 1 h. Original magnification: ×40 (A), ×100 (B, C, D, G, H); ×200 (E).