Effect of indomethacin on electrical field stimulation-induced contractions of isolated transverse and longitudinal rat gastric fundus strips

Figure 2 Effect of diazoxide (10^-4 mol/L) on cumulative concentration-response curves for relaxant effect of indomethacin on EFS-induced contractions of transverse (A) and longitudinal (B) strips of rat gastric fundus. Each point represents the mean ± SE of responses observed in eight strips. Relaxations or early contractions are expressed as percentages of the amplitude of contractions induced in the same strip by EFS before drug treatment. A: Responses of transverse strips of rat gastric fundus pretreated with diazoxide (◇) after administration of each concentration of indomethacin compared to saline-treated (◆) strips; B: responses of longitudinal strips of rat gastric fundus pretreated with diazoxide (□) after administration of each concentration of indomethacin compared to saline-treated (■) strips. ^aP < 0.05 vs saline-treated strips.