Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

Figure 2 Assignment of breaks in 7 patients with GC and 10 established cell lines. A total of 630 breaks were identified by SKY. Closed and open circles represent diffuse type and intestinal type, respectively. Open triangle represents the breakpoints obtained from one cell line MKN1 established from a GC patient with adenosquamous cell carcinoma. Mapping analysis of breaks to the ideograms delineated two outstanding loci, 8q24.1 and 11q13. The other breakpoints highlighted are 13q14, 17q11.2, 18q21, and 20q11.2.