Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis

doi:10.3748/wjg.v11.i33.5185

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Sep 7, 2005 (publication date) through Aug 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2005; 11(33): 5185-5192
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5185

Table 3 Effects of L. salivarius ssp. salivarius (5×10⁸ CFU/rat·d) treatment on macroscopic damage score, extent of the inflammatory lesion along the colon and changes in colon weight in TNBS experimental colitis in rats

Group (n = 10)	Damage score(0-10)	Extent of damage(cm)	Colon weight(mg/cm)
Non-colitic	0	0	63.3±2.5
TNBS control	6.5 (5-8)	3.4±0.3	209.7±17.0
TNBS probiotic	5 (3-7)^a	2.3±0.4^b	143.3±11.8^b

Damage score for each rat was assigned according to the criteria described in Table 1 and data are expressed as median (range). Extent of damage and colon weight data are expressed as mean±SE.

^aP<0.05,

^bP<0.01 vs TNBS control. All colitic groups differ significantly from non-colitic group.

Citation: Peran L, Camuesco D, Comalada M, Nieto A, Concha A, Diaz-Ropero MP, Olivares M, Xaus J, Zarzuelo A, Galvez J. Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis. World J Gastroenterol 2005; 11(33): 5185-5192
URL: https://www.wjgnet.com/1007-9327/full/v11/i33/5185.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i33.5185