Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis

Table 3 Effects of L. salivarius ssp. salivarius (5×10⁸ CFU/rat·d) treatment on macroscopic damage score, extent of the inflammatory lesion along the colon and changes in colon weight in TNBS experimental colitis in rats

Group (n = 10)	Damage score(0-10)	Extent of damage(cm)	Colon weight(mg/cm)
Non-colitic	0	0	63.3±2.5
TNBS control	6.5 (5-8)	3.4±0.3	209.7±17.0
TNBS probiotic	5 (3-7)a	2.3±0.4b	143.3±11.8b

Damage score for each rat was assigned according to the criteria described in Table 1 and data are expressed as median (range). Extent of damage and colon weight data are expressed as mean±SE.

^aP<0.05,

^bP<0.01 vs TNBS control. All colitic groups differ significantly from non-colitic group.