Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

doi:10.3748/wjg.v11.i33.5129

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World Journal of Gastroenterology

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1007-9327

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Gastric Cancer

World J Gastroenterol. Sep 7, 2005; 11(33): 5129-5135
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5129

Table 1 Karyotypes according to SKY analysis on 10 cell lines derived from advanced gastric cancers

Cell line	Histologic grade¹	Site²	Representative karyotype³
MKN45	Poor	LT	85,XX,del (1) (q32), del (1) (q32), +der (1) t (1;2) (p34;q21), +der (1) t (1;2) (p34;q21), der (2) t (2;22) (p23;q11.2), +del
			(2) (q23), +der (3) t (3;8) (p21.3;q24.1), +der (4) H (9qter→9q22::4p12→4q35::11p11.2→11pter), +der (4) (9qter→9
			q22::4p12→4q35::11p11.2→11pter), +der (5) t (5;8) (q31;q22), +der (5) t (5;8) (q31;q22),
			der (6) t (1;6) (q25;q27), +der (7) t (7;12) (q32;q21), +der (7) t (7;11) (q11.1;q13), +der (7) t (7;11) (q11.1;q13),
			+der (7) t (7;11) (q11.1;q13), +der (7) t (7;9) (q11.2;q34),-8,-8, +9, +10, +der (10) t (8;10) (q23;p15),
			+der (10) t (8;10) (q23;p15), +del (11) (p11.2), +der (12) t (9;12) (p22;q24.1), +der (12) t (10;12) (q11.2;q12), +13, +13,
			+der (14) t (13;14) (q22;p11.2), +der (14) t (13;14) (q22;p11.2), +16, +16, +16, +der (17) t (12;17) (q22;p13),
			+i (17) (p11.1), +der (19) (19pter→19q13.4::7?
			→7?::11q23→11qter), +der (19) (19pter→19q11::8q21.2→8q24.1::20q13.1→20qter), +20, +20, +der (20) t (7;20)
			(q11.2;p12), +der (20) t (7;20) (q11.2;p12), +der (20) t (8;20) (p11.2;q11.2),
			+der (21) t (20;21) (p11.2;q11.2), +der (21) t (12;21)
			(p11.2;q22.3), +22, +22, +mar (6pter→6q21::20p13→20q11.2::7p11.2→7p15::8q22?8q24.1::18q21→18qter)
SNU1	Poor	AS	85,XXYY, +del (1) (p22), +del (1) (p22), -4, -5,-5, -11,-11, -13, -14, -17, -18, +20, +20, +20, +mar
SNU5	Poor	AS	74,XX,der (1) t (1;8) (p36.3;q24.1),der (1) t (X;1) (p11.4;p32), +der (1) t (X;1) (p11.4;p32), +der (2) t (2;11) (p21;q13),
			+der (2) t (2;11) (p21;q13), +2,-3,der (4) t (4;17) (q33;q23), +der (4) t (4;13) (q31;q32), +der (4) (4pter→4q12::13q14
			→13q22::10q24→10qter), +del (5) (q15), +del (5) (p12), +5, +6, der (7) t (7;11) (q36;q13), +del (7) (q32), +del (7) (q32),
			+der (7) (7pter→7q22::11q13→11q23::13q12→13qter), +der (7) t (7;8) (q36;q24.1), +der (8) t (8;13) (q24.1;q14), +
			der (8) t (8;13) (q24.1;q14), +9, +10, +der (10) t (2;10) (p21;q24), +der (10) t (10;15) (q22;q15), +11, +11, +11, +12,
			der (13) (14qter→14q13::13p13→13q32::17q23→17qter),
			+14, +14, +der (15) t (15;22) (p13;q11.2), +16, +i (17q) (p10), +19, +20, +20, +21,-22, +hsr, +dmin
SNU16	Poor	AS	74,XX,del (1) (p13), +hsr (1) (pter→q21::hsr::q21→qter), +2, +3, +6, +6, +6, +del (7) (q22), +del (7) (q22), del (7) (q32),
			der (7) t (7;8) (q22;q24.1),
			+der (8) t (8;11) (q24.1;q13), +9,del (10) (q22), +11, +der (11) (5pter→5p13::11p11.2→11q25::17q23→17qter), +
			12, +12, +13, +14, +der (15) (6pter→6p11.2→::hsr::15p11→15qter), +16, +17, +17, +18, +18, +19, +20, +20,
			+22, 30-50dmin
KMK2	Poor	AS	66,X,del (X) (p11.2) (q22),der (1) (20qter→20q13.1::1p36.1→1q23::8q22→8qter),
			der (1) (17qter→17q21::1p32→1q42::8q24.1→8qter), +der (1) (4qter→4q33::5q35→5q11.2::1p13?→q21::8q
			13→8qter), +der (1) t (1;5) (q21;q32),
			+der (2) t (2;3) (q33;q25),t (3;5) (q25-26.2;q31), +der (3) (3pter→3q24::11q13→11q14::4p12→4pter),
			der (5) del (5) (p12) del (5) (q21), +der (5) (12qter→12q24.1::5p15.1→5q22::13q12→13qter),
			+der (5) t (5;7) (q13;q32), del (6) (q12), del (6) (q12), +del (6) (q25), +der (6) t (6;14) (q21;q22),
			del (7) (q22), der (7) t (7;15) (p22;q13), +der (7) t (6;7) (q15;p15), +der (7) t (7;20) (p11.2;q13), der (8) t (8;17) (p23;q11.2),
			der (9) (Xpter→Xp11.2::8q24.3→8q24.1::9p13→9qter), +der (9) t (3;9) (?;?),
			del (10) (q22), +der (10) (14q?ter→14q?24::10p13→10q21::1p13→1p34::8q24.1→8q24.3::11q13.1→11q13.5
			::7p15→7p22::15q13→15qter),der (12) (12pter→12q22::11q13.3→11q21::3q21→3qter), +der (12) (3pter→
			3p21::12p13→12q24.3::Xq13→Xq22::6p21.3→6pter), +der (12) (17qter→17q11.2::12p11.2→12q24.1::13q12
			→ 13qter),-13,der (13) (13pter→13q14::8q24.1→8q24.3::11q13.3→11q23::12q24.1→12qter),del (14) (q22),
			del (15) (q15), der (16) t (1;16) (p36.1;q22),der (17) (17pter→17q11.2::
			11q13.3→11q21::3q26.2→3qter), +der (17) t (16;17) (q22;q11.2),
			der (18) (22qter→22q11.2::11q21→11q13.3::
			8q24.1→8q22::18p11.2→18qter), +der (18) t (14;18) (q24;q21.3),
			+der (20) t (12;20) (q22;q13.1), +der (20) (20pter→20q11.2::13q12→13q14::8q24.1→8q24.3::11q13.3→11qter),
			+der (20) (20pter→20q11.2::13q12→13q14::8q24.1→8q24.3::11q13.3→11qter), +21,
			+der (22) t (5;22) (p13;q11.2)
KHM14K	Poor	LN	56,X,-Y, +1, +der (3) del (3) (p?) del (3) (q?), +der (3) (9qter?9q13::3q21→3p11::22q11.2→22qter), +der (5) (5qter
			→5p15::3?→3?::22q11.2→22qter),i (5p) (q10), +der (6) (6pter→6q11::5?→5?::17q23→17qter),
			t (8;16) (p23;q22), +der (8) t (8;20) (p11.2;q13.1), der (9) t (9;16) (p13;q12.1), +der (9) t (3;9) (q25;q13), +11,
			der (12) t (5;12) (q13;p13),der (13) t (3;13) (p13;q14), (14;15) (q32;q15), -15, del (15) (q24),
			+der (18) t (3;18) (p21.3;q21.1), +20, +20, +20,der (21) t (15;21) (q11.2-q13;p11.1),-22
GT3TKBU	Ndiffer. mucin-producing	AS	49,der (X) (Xpter→Xq28::HSR::1q32→1qter), +der (X) (Xpter→Xq28::HSR::1q32→1qter),-Y,-1,
			der (1) t (1;8) (p32-36.1;q24.1),der (2) t (2;4) (p12;q12-21),del (3) (p13),del (6) (q25),der (7) t (2;7) (q23;q11.2),-8,i
			(8q), der (9) t (9;10) (p13;q22), der (7;10) (7qter→7p22::13q13→13q11:: 10p11.2→10qter),
			der (10) t (8;10) (q24;p13), +der (10)
			t (10;15) (q11.2;q22),der (11) t (4;11) (q27;q23),der (11) t (1;11) (p13;q13),der (13) t (11;13) (q13;p11.2),
			der (13) t (13;17) (p11.2;p12),der (14) (14qter→14q11.2::3p11→3p26::17q11.2→17q23::3p21→3p23::17q21
			→17qter), der (17) t (8;17) (q24;q11.2), der (17) t (17;19) (p11.2;q13.1), der (17) t (17;19), +del (18) (q21),
			+der (18) t (18;19) (q11.2;q13.1), -19,der (19) t (19;20) (p13.1;p12),
			+der (20) t (18;20) (q11.2;q11.2), +der (20) (8qter→8q24::20p11.2→20q11.2::2q33→2qter),
			+der (20) t (7;20) (q32;q11.2), der (21) t (4;21) (q12;p11.2),-22
MKN28	Moderate	LN	47, X, -X, del (1) (p22), +der (1) t (X;1) (q22-24;q32), del (2) (q13), del (2) (q13), +der (2) t (2;18) (p23;q21.3),
			der (3) del (3) (p13p25) del (3) (q21q25), +der (3) del (3) (p12) del (3) (q21q26.2), -4, -5, -5, -7,
			der (7) t (7;8) (q36;q22), -8, der (8) t (8;10) (p23;q11.2), -10, -13, der (14) t (7;14) (q11.2;q11.2),
			der (14) t (1;14) (q42;q24), +15, +der (16) t (13;16) (q12;q23-24),
			+der (19) t (11;19) (q13;q13.3), der (20) (20pter→20q13.1::8q13→8q24::7q32→7qter),
			+der (20) t (18;20) (q21.1;q11.2), +21, +21
MKN74	Moderate	LT	39, X, +der (X) (15qter→15q11.2::Xp11.2→Xq28::8q24.1→8qter),
			+der (X) t (X;7) (q13;q32), -Y, der (1) (9qter→9q32::1p34→1q32::18q21→18qter), +2, -3,
			der (4) t (4;6) (p12;p21.3), -5, der (7) (7pter→7q32::8q22→8q24.1::9q22→9qter), der (7) t (7;8) (q32;q22), der (8) t
			(8;10) (p23;q22), der (9) t (9;11) (q22;q13), -9, -10, +del (11) (q13), -12, -13,
			der (14) t (9;14) (q13;p11.2), -14, -15, der (16) t (9;16) (q13;q24), +der (16) t (9;16) (q13;q24) del (9) (q22),
			der (18) t (2;18) (?;q23), der (20) t (13;20) (q32;q11.1), -20, -21, -21, der (22) t (10;22) (q24;p11.2),
			+der (22) t (13;22) (q14;p11.2)
MKN1	Adenosqu amous carcinoma	LN	56, X, +inv (X) (p11.2p22.1), -Y, +der (1) t (1;8) (p36.1;q24.1), +der (1) t (1;8) (p36.1;q24.1),
			der (3) t (3;5) (p11;p12), der (3) t (3;20) (q27;q13.1),
			+der (3) t (3;7) (p26;q32.1), -5, -5, -6, +7, +7, +7, +7, del (8) (q24.1), +del (8) (q24.1),
			+del (8) (p11.2), +del (8) (p11.2), -9, -9, +ins (11;17) (q13;q11.2q25), -12, +del (13) (q14q22),
			der (15) t (4;15) (q12;p11.2), -15, +del (16) (q12.1), +del (16) (p11.2), +16, der (17) t (4;17) (p15.2;p11.2),
			der (17) t (4;17) (p15.2;p11.2), del (17) (q11.2), +der (18) t (3;18) (q21;q11.2), del (18) (q11.2),
			del (19) (p13.1), der (19) t (19;21) (q13.1;q11.2), +der (19) t (19;21) (q13.1;q11.2), +del (20) (q11.2),
			+der (20) t (17;20) (q23;q11.2), der (22) t (11;22) (p13;p11.2)

¹Poor: poorly differentiated adenocarcinoma; Moderate, moderately differentiated adenocarcinoma.

²ST: stomach; LT: metastatic liver tumor; AS: ascitic fluid; LN: lymph node. 3Representative karyotypes are defined based on G-banding and SKY findings, and described according to ISCN1995.

Citation: Yamashita Y, Nishida K, Okuda T, Nomura K, Matsumoto Y, Mitsufuji S, Horiike S, Hata H, Sakakura C, Hagiwara A, Yamagishi H, Taniwaki M. Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping. World J Gastroenterol 2005; 11(33): 5129-5135
URL: https://www.wjgnet.com/1007-9327/full/v11/i33/5129.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i33.5129