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©The Author(s) 2005.
World J Gastroenterol. Sep 7, 2005; 11(33): 5103-5108
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5103
Published online Sep 7, 2005. doi: 10.3748/wjg.v11.i33.5103
Table 4 Interactive effect between lifetime alcohol consumption and ADH2 and ALDH2 genotypes on esophageal cancer risk
| ADH2 | ALDH2 | Alcohol consumption (g/yr) | Cases (%) n = 134 | Controls (%) n = 237 | OR (95%CI) | AOR (95%CI)1 |
| *1/*2 or *2/*2 | *1/*1 | Non-drinker | 3 (2.2) | 66 (27.9) | 1 | 1 |
| ≤1 500 | 5 (3.7) | 19 (8.0) | 5.79 (1.27-26.46) | 3.76 (0.65-21.69) | ||
| >1 500 | 15 (11.2) | 27 (11.4) | 12.22 (3.27-45.66) | 6.07 (1.46-25.26) | ||
| *1/*1 | *1/*1 | Non-drinker | 0 | 2 (0.8) | – | – |
| ≤1 500 | 4 (3.0) | 4 (1.7) | 22.00 (3.62-133.81) | 14.91 (1.92-115.95) | ||
| >1 500 | 5 (3.7) | 2 (0.8) | 55.00 (7.39-409.22) | 33.54 (3.52-319.89) | ||
| *1/*2 or *2/*2 | *1/*2 | Non-drinker | 13 (9.7) | 76 (32.1) | 3.76 (1.03-13.78) | 2.92 (0.73-11.63) |
| ≤1 500 | 31 (23.1) | 15 (6.3) | 45.47 (12.26-168.68) | 26.67 (6.05-117.57) | ||
| >1 500 | 25 (18.7) | 7 (3.0) | 78.57 (18.83-327.89) | 39.26 (7.05-218.68) | ||
| *1/*1 | *1/*2 | Non-drinker | 5 (3.7) | 6 (2.5) | 18.33 (3.50-96.18) | 18.60 (2.69-128.77) |
| ≤1 500 | 14 (10.5) | 1 (0.4) | 308 (29.80-3 183.05) | 139.35 (10.05-∞) | ||
| >1 500 | 11 (8.2) | 0 | – | – | ||
| *1/*2 or *2/*2 | *2/*2 | Non-drinker | 3 (2.2) | 11 (4.6) | 6 (1.07-33.60) | 2.20 (0.33-14.47) |
| ≤1 500 | 0 | 0 | – | – | ||
| >1 500 | 0 | 0 | – | – | ||
| *1/*1 | *2/*2 | Non-drinker | 0 | 1 (0.4) | – | – |
| ≤1 500 | 0 | 0 | – | – | ||
| >1 500 | 0 | 0 | – | – |
- Citation: Wu CF, Wu DC, Hsu HK, Kao EL, Lee JM, Lin CC, Wu MT. Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. World J Gastroenterol 2005; 11(33): 5103-5108
- URL: https://www.wjgnet.com/1007-9327/full/v11/i33/5103.htm
- DOI: https://dx.doi.org/10.3748/wjg.v11.i33.5103