Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males

Table 2 Association of ADH2 and ALDH2 genotypes with esophageal cancer risk before and after adjusting for other covariates

Genotypes	Cases (%) n = 134	Controls (%) n = 237	OR (95%CI)	AOR (95%CI)1
ADH2
*2/*2	46 (34.3)	130 (54.9)	1	1
*1/*2	49 (36.6)	91 (38.4)	1.52 (0.94–2.47)	2.28 (1.11–4.68)
*1/*1	39 (29.1)	16 (6.8)	6.89 (3.52–13.49)	7.14 (2.76–18.46)
P for HW2		1.00
ALDH2
*1/*1	32 (23.9)	120 (50.6)	1	1
*1/*2	99 (73.9)	105 (44.3)	3.54 (2.19–5.70)	5.25 (2.47–11.19)
*2/*2	3 (2.2)	12 (5.1)	0.94 (0.25–3.52)	2.44 (0.44–13.55)
P for HW2		0.38

¹Adjusting for age (continuous variable), educational levels (high school vs <high school; >high school vs <high school), cigarette smoking (yes vs no), alcohol consumption (yes vs no), areca chewing (yes vs no), and ADH2 (*1/*1 vs *2/*2 and *1/*2 vs *2/*2) or ALDH2 (*2/*2 vs *1/*1 and *1/*2 vs *1/*1). 2P value for deviation from Hardy–Weinberg equilibrium.