CXCL16 participates in pathogenesis of immunological liver injury by regulating T lymphocyte infiltration in liver tissue

Figure 7 Effects of anti-CXCL16 antibody on intrahepatic infiltration of T lymphocytes and serum ALT level in the mice. Mice were primed with BCG and sequentially challenged by LPS 12 d after priming. Anti-CXCL16 antibody and isotype antibody were administrated into the mice, respectively. A: T lymphocytes derived from the mice treated with either anti-CXCL16 antibody (closed bars) or isotype antibody (hatched bars) was harvested for FACS analysis. The absolute number of T lymphocytes was determined by multiplying the total MNC number by the fraction of CD3+T lymphocytes population. ^aP<0.05 vs control Ab treatment. B: Anti-CXCL16 antibody significantly suppressed the elevation of serum ALT. ^bP<0.01 vs control Ab group. Results were obtained from three independent experiments.