MUC1 and MUC5AC mucin expression in liver fluke-associated intrahepatic cholangiocarcinoma

Table 4 Significant prognostic factors for disease-free survival by multivariate analysis

Variables	Crude HR (95%CI)	Adjusted HR (95%CI)	P
MUC1 expression			0.026
Low	1	1
High	2.59 (1.54-4.35)	2.19 (1.11-4.32)
MUC5AC expression			0.059
Low	1	1
High	1.36 (0.83-2.24)	2.06 (0.96-4.41)
Age (yr)			0.571
≤56	1	1
>56	0.86 (0.53-1.42)	1.19 (0.65-2.17)
Gender			0.128
Male	1	1
Female	0.63 (0.37-1.09)	0.60 (0.31-1.18)
Histological grading			<0.050
Papillary	1	1
Well-differentiated	1.86 (0.91-3.83)	1.92 (0.82-4.49)
Moderately differentiated	3.65 (1.59-8.41)	3.00 (1.10-8.20)
Poorly differentiated	1.78 (0.70-4.53)	3.02 (0.97-9.41)
Staging			<0.050
I–III	1	1
IVA	2.49 (0.81-7.62)	5.10 (1.27-20.43)
IVB	3.57 (1.41-9.00)	3.93 (1.47-10.51)