ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9

Figure 3 EMSA for NF-kB DNA binding activity. EMSA for NF-kB DNA binding activity. Lane 1: 100 folded excess unlabeled oligonucleotides; lane 2: control group; lanes 3 and 4: Pe (4 wk); lanes 5 and 6: Pe (6 wk); lanes 7 and 8: Mo (4 wk); lane 9: Mo (6 wk). NF-kB DNA binding activity markedly increased in model group, perindopril treatment considerably reduced NF-kB activity. Binding specificity was demonstrated by competition of excess unlabeled oligonucleotides containing the kB site. Results are representative of three independent experiments.