ACEI attenuates the progression of CCl4-induced rat hepatic fibrogenesis by inhibiting TGF-β1, PDGF-BB, NF-κB and MMP-2,9

Figure 1 Masson staining of liver sections in perindopril treated-group (6 wk, panel A) and model group (6 wk, panel B). Perindopril [2 mg/(kg•d)] was administered for 6 wk. Less proliferation of fibrotic septa and marked fatty degeneration in the portal tract are evident in panel A (final magnification 100×).While in panel B, the lobule is disorderly, and wide portal to portal fibrotic septa is evident. Extensive fatty degeneration is present around portal tracts and the central veins (final magnification 100×).