Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas

Table 4 Multivariate-adjusted1 joint and combined associations of VDR Tru9I genotypes and various risk factors for colorectal neoplasms and risk for incident sporadic colorectal adenomas, MAP study, 1994-1997

	UU			Uu+uu
	Cases (n)	Controls (n)	OR2/95%CI3	Cases (n)	Controls (n)	OR/95%CI
Age (yr)
≤57	58	83	1	12	31	0.60 (0.26-1.37)
>57	86	89	1.41 (0.86-2.31)	15	18	1.09 (0.46-2.56)
Sex
Male	85	60	1	15	16	0.65 (0.28-1.53)
Female	59	112	0.51 (0.30-0.85)	12	33	0.38 (0.17-0.88)
Current smoker
No	35	77	1	6	25	0.39 (0.13-1.23)
Yes	105	94	1.84 (1.07-3.17)	20	24	1.56 (0.69-3.53)
Current drinker
No	63	99	1	13	26	0.96 (0.44-2.08)
Yes	77	71	1.65 (1.01-2.69)	12	22	0.90 (0.39-2.06)
NSAID4 use
No	118	117	1	21	38	0.64 (0.34-1.23)
Yes	23	54	0.48 (0.26-0.86)	5	11	0.38 (0.12-1.25)
Total calcium intake5
Lower	92	84	1	13	23	0.53 (0.23-1.20)
Higher	49	86	0.53 (0.32-0.87)	14	26	0.52 (0.23-1.14)
Total vitamin D intake6
Lower	76	83	1	14	25	0.59 (0.26-1.33)
Higher	65	87	0.78 (0.48-1.27)	13	24	0.60 (0.27-1.38)

¹Adjusted for age, sex, total energy intake, history of colon cancer in a first degree relative, nonsteroidal anti-inflammatory drug use, current smoking status, and total calcium and alcohol intakes; ²odds ratio; ³95% confidence interval; ⁴nonsteroidal anti-inflammatory drug; ⁵sex-specific median calcium intakes for males 701.3 mg/d, for females 754.1 mg/d; ⁶sex-specific median vitamin D intakes for males 257.2 IU/d, for females 229.7 IU/d.