Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas

Table 3 Age-, sex-adjusted associations of VDR Tru9I genotypes and risk for incident sporadic colorectal adenomas according to adenoma characteristics, MAP Study, 1994-1997

Adenoma characteristics	Tru9I genotypes
	UU		Uu+uu
	Cases/controls (n)	OR1/95%CI2	Cases/controls (n)	OR/95%CI
Multiplicity
1	85/171	1.00	20/49	0.88 (0.48-1.60)
>1	59/171	1.00	7/49	0.51 (0.21-1.24)
Shape
Sessile	51/171	1.00	5/49	0.36 (0.13-0.97)
Pedunculated	97/171	1.00	22/49	0.93 (0.51-1.68)
Size (cm)3
<1.0	111/171	1.00	24/49	0.84 (0.47-1.49)
≥1.0	33/171	1.00	3/49	0.37 (0.11-1.28)
Dysplasia4
Mild	73/171	1.00	15/49	0.79 (0.41-1.53)
≥Moderate	71/171	1.00	12/49	0.68 (0.33-1.41)
Morphology5
Tubular	131/171	1.00	27/49	0.80 (0.46-1.38)
Any villous	13/171	1.00	0/49	NA6

¹Odds ratio;

²95% confidence interval; ³greatest diameter of largest adenoma; ⁴dysplasia in adenoma with greatest degree of dysplasia; ⁵if multiple adenomas, classified as “Any villous” if any adenoma villous or tubulovillous; ⁶not available.