Mutations in hepatitis B virus core regions correlate with hepatocellular injury in Chinese patients with chronic hepatitis B

Figure 1 Comparison of core amino acid sequences between eAg-Po and eAg-Ne groups. (A) and between HA and LA groups (B). The top line is the core amino acid sequence of the HBV adr subtype. Core amino acid sequences of the HA group are C-1, C-2, C-3, C-11, C-16, C-22, C-29, C-35, C-36, and C-39, and those of the LA group are C-4, C-6, C-8, C-9, C-13, C-17, and C-21, Each dot denotes an identical match to the top sequence. An asterisk denotes that this codon is a stop codon. a,b,c are HLA class II-restricted T cell recognition sites. d, e, f are HLA class I-restricted CTL epitopes. g, h are the lesion exposed at the surface of HBcAg.