Biological impacts of &ldquo;hot-spot&rdquo; mutations of hepatitis B virus X proteins are genotype B and C differentiated

doi:10.3748/wjg.v11.i30.4703

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Aug 14, 2005 (publication date) through Jul 20, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Aug 14, 2005; 11(30): 4703-4708
Published online Aug 14, 2005. doi: 10.3748/wjg.v11.i30.4703

Table 3 Summary of the biological impact of “hot-spot” mutations on genotype B and C HBx

HBx mutants	Genotype B¹		Genotype C²
HBx mutants	Transactivation	Antiproliferation	Transactivation	Antiproliferation
I127T	↑³	↑	↑	-⁵
I127T+K130M+V131I	↑	↑	-	-
K130M+V131I	↓⁴	↓	-	↓
K130M+V131I+F132Y	↓	↓	-	↑
F132Y	↓	↓	-	↓

¹Changes of biological functions were compared with XB;

²Changes of biological functions were compared with XC. ^3,4,and⁵ accordingly indicate increased, decreased and equal activities of HBx mutants as compared with XB/XC.

Citation: Lin X, Xu X, Huang QL, Liu YQ, Zheng DL, Chen WN, Lin JY. Biological impacts of “hot-spot” mutations of hepatitis B virus X proteins are genotype B and C differentiated. World J Gastroenterol 2005; 11(30): 4703-4708
URL: https://www.wjgnet.com/1007-9327/full/v11/i30/4703.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i30.4703