Temporal expression of hepatic inducible nitric oxide synthase in liver cirrhosis

Figure 4 Hepatic NOS activity in the course of cirrhosis development. At different time points after operation, hepatocytes were isolated and NOS activity was determined by L-citrulline generation assay as described in Materials and Methods. 3d-4 wk, three days to four weeks after BDL or sham operation. ^bP<0.01 for sham-operated versus BDL at each time points; ^eP<0.05 for 3 wk vs all other time points after BDL except 4 wk. A: Total NOS activity, ^dP<0.01 for 1 wk vs all other points except 2 wk after BDL; B: iNOS activity, ^cP<0.05 for 1 wk vs 3 d and 2 wk after BDL.