NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different?

doi:10.3748/wjg.v11.i3.407

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 21, 2005; 11(3): 407-411
Published online Jan 21, 2005. doi: 10.3748/wjg.v11.i3.407

Table 2 NOD2/CARD15 genotypes and allele frequencies in Hungarian IBD patients.

	Patients	Genotypes			Allele frequency (%)	P value¹
	Patients	-/- n (%)	-/+ n (%)	+/+ n (%)	Allele frequency (%)	P value¹
Arg702Trp	CD	129 (87.2)	17 (11.5)	2 (1.4)	7.1	0.01¹
	UC	120 (93.8)	8 (6.3)	0	3.1	0.07²
	Controls	197 (94.7)	11 (5.3)	0	2.6	n.s.³
Gly908Arg	CD	139 (93.9)	9 (6.1)	0	3	0.10¹
	UC	124 (96.9)	4 (3.1)	0	1.6	0.27²
	Controls	203 (97.4)	5 (2.6)	0	1.2	n.s.³
1007finsC	CD	122 (82.4)	22 (14.9)	5 (3.4)	10.8	<0.0001¹
	UC	122 (95.3)	6 (4.7)	0	2.3	0.001²
	Controls	199 (95.7)	9 (4.3)	0	2.2	n.s.³

Crohn’s disease (CD, n = 148), ulcerative colitis (UC, n = 128) and controls (n=208); Genotypes: -/- homozygous wild-type, -/+ heterozygous mutant, +/+ homozygous mutant; Absolute numbers (percentages) of individuals negative (-/-), heterozygous (-/+), homozygous (+/+) for the different NOD2/CARD15 mutations (Arg702Trp, Gly908Arg and 1007finsC) are shown. Fisher’s exact test was performed comparing percentages of patients positive or negative for the corresponding NOD2/CARD15 mutation between

¹CD and controls,

²CD and UC,

³UC and controls.

Citation: Büning C, Molnar T, Nagy F, Lonovics J, Weltrich R, Bochow B, Genschel J, Schmidt H, Lochs H. NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: Is Hungary different? World J Gastroenterol 2005; 11(3): 407-411
URL: https://www.wjgnet.com/1007-9327/full/v11/i3/407.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i3.407