Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs

Figure 1 Effect of different coating levels on SM·HCl release behavior from the coated pellets in distilled water (n = 6). A: Pellets coated at five levels of 0% (◇), 3% (□), 5% (△), 6.5% (○), 8% (●, w/w, total solid applied); B: rapid-release pellets (▲) and slow-release pellets at a 6.5% coating level (△) and a mixture of slow- and rapid-release pellets (9:1, w/w, ●).