Antibody to eosinophil cationic protein suppresses dextran sulfate sodium-induced colitis in rats

Figure 2 Colonic mucosa at 3 d post-DSS treatment showing eosinophils in the lamina propria. HE staining (A) and immunostaining for ECP (B) as described under Materials and methods. ECP-positive cells (brown) appear in close proximity to damaged crypts in the lamina propria and partially in the extracellular interstitium of DSS-induced colitis. Original magnification, ×400. Colonic mucosa at 7-d treatment of DSS. (C) Colonic ulceration in normal serum-treated rats. (D) Reduced severity of colonic mucosal ulceration in anti-ECP-treated rats. HE stain. Original magnification, ×100.