Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs

doi:10.3748/wjg.v11.i29.4547

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Aug 7, 2005 (publication date) through Dec 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2005; 11(29): 4547-4551
Published online Aug 7, 2005. doi: 10.3748/wjg.v11.i29.4547

Table 1 Pharmacokinetic parameters after oral administration of either SM·HCl 24-h test sustained-release pellets or 12-h reference sustained-release tablets in beagle dogs at a single dose of 120 mg/animal (n = 6, mean±SD)

Parameter	Test formulation	Reference formulation
Cmax (ng/mL)	893.1±119.4	1 334.5±150.5
tmax (h)	9.83±0.40	2.67±0.21
Ke (1/h)	0.044±0.01	0.084±0.01
t0.5 (h)	20.7±8.7	8.6±1.9
AUC0–tn (mg·h/L)	13.50±1.47	13.06±9.45
F (%)	103.41	-

Citation: Sun J, Shi JM, Zhang TH, Gao K, Mao JJ, Li B, Sun YH, He ZG. Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs. World J Gastroenterol 2005; 11(29): 4547-4551
URL: https://www.wjgnet.com/1007-9327/full/v11/i29/4547.htm
DOI: https://dx.doi.org/10.3748/wjg.v11.i29.4547