CYP2E1-dependent hepatotoxicity and oxidative damage after ethanol administration in human primary hepatocytes

Table 1 Ethanol exposure of hepatocytes causes cellular damage in human hepatocytes

Group	MDA(nmol/mg protein)	LDH (U/L)	AST (U/L)
CT	36.37±3.64	15.6±1.66	94.22±9.52
100 mmol/L ethanol	69.05±4.41	84.5±7.86	181.91±11.55
100 mmol/L ethanol plus	65.31±9.32	80.4±8.86	174.51±17.12
25 µmol/L DAS
100 mmol/L ethanol plus	59.54±7.02	75.5±7.06	160.42±17.86
50 µmol/L DAS
100 mmol/L ethanol plus	56.13±6.32a	70.8±6.24a	156.42±15.55a
100 µmol/L DAS
25 µmol/L DAS	37.43±3.45	16.7±1.85	93.056±9.64
50 µmol/L DAS	36.43±4.15	15.8±1.33	92.16±9.04
100 µmol/L DAS	38.43±4.05	17.6±1.95	96.32±10.08

^aP<0.05 vs 100 mmol/L ethanol (n = 5).