Expression of adhesion molecules on mature cholangiocytes in canal of Hering and bile ductules in wedge biopsy samples of primary biliary cirrhosis

Figure 5 (PDF) Immunoelectron microscopic findings of ICAM-1 ( A, C, and E) and LFA-1 ( B, D, and F) in periportal small bile ductule and canal of Hering in PBC liver. A: Gold-labeled ICAM-1 particles on the surface of cholangiocytes (arrowhead) facing the lumen of small bile ductule, a small portal or peripheral blood vessel, and also on sinusoidal endothelial cells (arrowheads). BD denotes bile ductule; B: Lymphocytes with dense labeling of LFA-1 (arrowhead) around small ductule; C: Gold-labeled ICAM-1 particles on the luminal surfaces of hepatocytes and cholangiocytes of CoH, on bile canaliculus and also on sinusoidal endothelial cells (arrows); D: Lymphocytes densely labeled with LFA-1 (arrows) on the basolateral membrane of cholangiocytes of the CoH; E:No ICAM-1 immunoreactivity show immature cells resembling progenitor cells (asterisk) in CoH, and these cells; F: No infiltration of lymphocytes is observed around the progenitor-like cells (asterisk). Bar, 5 mm; BD, bile ductile; Ly, lymphocyte; CoH, canal of Hering; H. hepatocyte. Uranyl acetate stain.