Treatment of metastatic colorectal carcinomas by systemic inhibition of vascular endothelial growth factor signaling in mice

Figure 7 (PDF) Effective inhibition of tumor angiogenesis in vivo by treatment with AdsFlt1-3. Pre-established CRC tumors were treated with AdLacZ or AdsFlt1-3. Animals were killed on d 9 after treatment and tumor tissue was removed. Microvessel density was determined by anti-von Willebrand factor staining. A and B: Representative photomicrographs show microvessel staining in tumors of AdLacZ- or AdsFlt1-3-treated mice; C: quantitative analysis of microvessel density was made by counting the positively stained cells per high-power fields (200× magnification). Data are given as mean of cell number/HPF and SE (P = 0.02 compared to the control).