Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents

Figure 2 Ionic basis of TMP-induced I_SC. A: One millimole per liter of TMP-induced I_SC response (total charge transfer per unit area over 30-min period) obtained in various solutions was plotted with normal KH solution as the control; B: Summarized data showing the effect of 1 mmol/L of TMP-evoked I_SC response in the apical presence of amiloride (0.1 mmol/L), apical Na⁺ removal, and basolateral Na⁺ removal from the bath solution. Values are mean±SE; ^bP < 0.001, ^dP < 0.01 vs control. NS, not significant.