Tetramethylpyrazine stimulates cystic fibrosis transmembrane conductance regulator-mediated anion secretion in distal colon of rodents

Figure 1 Effect of TMP on ion transport across rat colonic mucosa. A: Representative recordings of I_SC response to TMP (0.1, 1.0, 3.0, and 5.0 mmol/L) added to basolateral side. Arrowheads indicate the time of addition of TMP; B: Concentration-response curve of TMP with response indicated by the total charge transfer per unit area over a 30-min period. Each data point was obtained from at least four individual experiments. Values are mean±SE of maximal increase in I_SC.