Effect of itopride, a new prokinetic, in patients with mild GERD: A pilot study

Table 2 Changes of acid reflux variables and DeMeester score in 26 patients with GERD after treatment with 150 or 300 mg of itopride

Variable	Group (mg/d)	Itopride Tx.	n	Mean	SD	P
Number of acid refluxes	150	Pre	12	99.25	88.57	0.97
		Post	12	76.92	60.53
	300	Pre	13	150.77	246.15	0.057
		Post	13	52.23	39.79
Number of acid refluxes longer than 5 min	150	Pre	12	6.08	5.32	0.287
		Post	12	3.83	5.32
	300	Pre	13	6.23	5.12	0.054
		Post	13	2.69	2.5
Longest time acid refluxes (min)	150	Pre	12	30.55	33.37	0.018
		Post	12	14.09	11.03
	300	Pre	13	30.25	56.4	0.289
		Post	13	20.78	33.64
Total time below pH 4 (min)	150	Pre	12	138.42	98.56	0.16
		Post	12	92.09	78.07
	300	Pre	13	145.08	86.1	0.011
		Post	13	71.77	51.43
Fraction time below pH 4 (%)	150	Pre	12	11.13	9.26	0.211
		Post	12	10.12	12.69
	300	Pre	13	11.2	6.69	0.005
		Post	13	5.27	3.57
DeMeester score	150	Pre	12	32.5	16.96	0.16
		Post	12	22.89	18.75
	300	Pre	13	44.48	37.5	0.007
		Post	13	19.56	14.72